N402_4e 86..90
نویسندگان
چکیده
86 NATURE | VOL 402 | 4 NOVEMBER 1999 | www.nature.com Calculation of correlated mRNA expression Results of 97 individual publicly available DNA chip yeast mRNA expression data sets were encoded as a string of 97 numbers associated with each yeast open reading frame (ORF) describing how the mRNA of that ORF changed levels during normal growth, glucose starvation, sporulation and expression of mutant genes. This string is the analogue within one organism of a phylogenetic pro®le. The mRNA levels for each of the 97 experiments were normalized, and only genes that showed a two-standard-deviation change from the mean in at least one experiment were accepted, thereby ignoring genes that showed no change in expression levels for any experiment. Open reading frames with correlated expression patterns were grouped together by calculating the 97-dimensional euclidean distance that describes the similarity in mRNA expression patterns. Open reading frames were considered to be linked if they were among the 10 closest neighbours within a given distance cut-off, conditions that maximized the overlap of ORF annotation between neighbours.
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